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Idiopathic inflammatory myopathy

MedGen UID:
148290
•Concept ID:
C0751356
•
Disease or Syndrome
Synonyms: Idiopathic Inflammatory Myopathies; Idiopathic Inflammatory Myopathy; Idiopathic Inflammatory Myositis; Inflammatory Myopathies, Idiopathic; Inflammatory Myopathy, Idiopathic; Myopathies, Idiopathic Inflammatory; Myopathy, Idiopathic Inflammatory
SNOMED CT: Idiopathic inflammatory myopathy (702380008); Idiopathic inflammatory myositis (702380008)
 
Monarch Initiative: MONDO:0600023

Definition

An umbrella term for diseases which have chronic muscle inflammation and weakness of unknown etiology. The types of idiopathic inflammatory myopathy are further defined by either clinicopathologic criteria or by the presence of certain autoantibodies. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIdiopathic inflammatory myopathy
Follow this link to review classifications for Idiopathic inflammatory myopathy in Orphanet.

Professional guidelines

PubMed

International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative.
Oldroyd AGS, Callen JP, Chinoy H, Chung L, Fiorentino D, Gordon P, Machado PM, McHugh N, Selva-O'Callaghan A, Schmidt J, Tansley SL, Vleugels RA, Werth VP; International Myositis Assessment and Clinical Studies Group Cancer Screening Expert Group, Aggarwal R
Nat Rev Rheumatol 2023 Dec;19(12):805-817. Epub 2023 Nov 9 doi: 10.1038/s41584-023-01045-w. PMID: 37945774Free PMC Article
Juvenile Dermatomyositis: Advances in Pathogenesis, Assessment, and Management.
Leung AKC, Lam JM, Alobaida S, Leong KF, Wong AHC
Curr Pediatr Rev 2021;17(4):273-287. doi: 10.2174/1573396317666210426105045. PMID: 33902423
Clinical manifestations and treatment of antisynthetase syndrome.
Marco JL, Collins BF
Best Pract Res Clin Rheumatol 2020 Aug;34(4):101503. Epub 2020 Apr 11 doi: 10.1016/j.berh.2020.101503. PMID: 32284267

Recent clinical studies

Etiology

Paraneoplastic myopathies.
Mammen AL
Handb Clin Neurol 2024;200:327-332. doi: 10.1016/B978-0-12-823912-4.00022-0. PMID: 38494286
Lipid-lowering Therapies in Myositis.
Mizus MC, Tiniakou E
Curr Rheumatol Rep 2020 Aug 26;22(10):70. doi: 10.1007/s11926-020-00942-3. PMID: 32845379Free PMC Article
Dermatomyositis: Clinical features and pathogenesis.
DeWane ME, Waldman R, Lu J
J Am Acad Dermatol 2020 Feb;82(2):267-281. Epub 2019 Jul 4 doi: 10.1016/j.jaad.2019.06.1309. PMID: 31279808
Juvenile Idiopathic Inflammatory Myopathies.
Huber AM
Pediatr Clin North Am 2018 Aug;65(4):739-756. doi: 10.1016/j.pcl.2018.04.006. PMID: 30031496
Noninflammatory myopathies.
Baer AN, Wortmann RL
Rheum Dis Clin North Am 2013 May;39(2):457-79. Epub 2013 Mar 16 doi: 10.1016/j.rdc.2013.02.006. PMID: 23597974

Diagnosis

A Review of Antisynthetase Syndrome-Associated Interstitial Lung Disease.
Patel P, Marinock JM, Ajmeri A, Brent LH
Int J Mol Sci 2024 Apr 18;25(8) doi: 10.3390/ijms25084453. PMID: 38674039Free PMC Article
Lipid-lowering Therapies in Myositis.
Mizus MC, Tiniakou E
Curr Rheumatol Rep 2020 Aug 26;22(10):70. doi: 10.1007/s11926-020-00942-3. PMID: 32845379Free PMC Article
Dermatomyositis: Clinical features and pathogenesis.
DeWane ME, Waldman R, Lu J
J Am Acad Dermatol 2020 Feb;82(2):267-281. Epub 2019 Jul 4 doi: 10.1016/j.jaad.2019.06.1309. PMID: 31279808
Juvenile Idiopathic Inflammatory Myopathies.
Huber AM
Pediatr Clin North Am 2018 Aug;65(4):739-756. doi: 10.1016/j.pcl.2018.04.006. PMID: 30031496
Idiopathic inflammatory myopathies.
Amato AA, Barohn RJ
Neurol Clin 1997 Aug;15(3):615-48. doi: 10.1016/s0733-8619(05)70337-6. PMID: 9227956

Therapy

Juvenile Dermatomyositis: Diagnosis and Management.
Aounallah A, Saad S, Ghariani Fetoui N, Denguezli M
Skinmed 2024;22(4):272-275. Epub 2024 Sep 17 PMID: 39285567
Use of Janus kinase inhibitors in dermatomyositis: a systematic literature review.
Paik JJ, Lubin G, Gromatzky A, Mudd PN Jr, Ponda MP, Christopher-Stine L
Clin Exp Rheumatol 2023 Mar;41(2):348-358. Epub 2022 Jun 28 doi: 10.55563/clinexprheumatol/hxin6o. PMID: 35766013Free PMC Article
Juvenile Dermatomyositis: Advances in Pathogenesis, Assessment, and Management.
Leung AKC, Lam JM, Alobaida S, Leong KF, Wong AHC
Curr Pediatr Rev 2021;17(4):273-287. doi: 10.2174/1573396317666210426105045. PMID: 33902423
Juvenile Idiopathic Inflammatory Myopathies.
Huber AM
Pediatr Clin North Am 2018 Aug;65(4):739-756. doi: 10.1016/j.pcl.2018.04.006. PMID: 30031496
Management of Myositis-Related Interstitial Lung Disease.
Morisset J, Johnson C, Rich E, Collard HR, Lee JS
Chest 2016 Nov;150(5):1118-1128. Epub 2016 Apr 19 doi: 10.1016/j.chest.2016.04.007. PMID: 27102182

Prognosis

Diagnostic and prognostic value of anti-cN1A antibodies in inclusion body myositis.
Salam S, Dimachkie MM, Hanna MG, Machado PM
Clin Exp Rheumatol 2022 Feb;40(2):384-393. Epub 2022 Jan 25 doi: 10.55563/clinexprheumatol/r625rm. PMID: 35225226
Juvenile dermatomyositis. Where are we now?
McCann LJ, Livermore P, Wilkinson MGL, Wedderburn LR
Clin Exp Rheumatol 2022 Feb;40(2):394-403. Epub 2022 Feb 7 doi: 10.55563/clinexprheumatol/56ilob. PMID: 35225221
Clinical manifestations and treatment of antisynthetase syndrome.
Marco JL, Collins BF
Best Pract Res Clin Rheumatol 2020 Aug;34(4):101503. Epub 2020 Apr 11 doi: 10.1016/j.berh.2020.101503. PMID: 32284267
Dermatomyositis: Clinical features and pathogenesis.
DeWane ME, Waldman R, Lu J
J Am Acad Dermatol 2020 Feb;82(2):267-281. Epub 2019 Jul 4 doi: 10.1016/j.jaad.2019.06.1309. PMID: 31279808
Juvenile Idiopathic Inflammatory Myopathies.
Huber AM
Pediatr Clin North Am 2018 Aug;65(4):739-756. doi: 10.1016/j.pcl.2018.04.006. PMID: 30031496

Clinical prediction guides

Current Biomarker Strategies in Autoimmune Neuromuscular Diseases.
Oeztuerk M, Henes A, Schroeter CB, Nelke C, Quint P, Theissen L, Meuth SG, Ruck T
Cells 2023 Oct 15;12(20) doi: 10.3390/cells12202456. PMID: 37887300Free PMC Article
Rapid and sustained response to JAK inhibition in a child with severe MDA5 + juvenile dermatomyositis.
Strauss T, Günther C, Schnabel A, Wolf C, Hahn G, Lee-Kirsch MA, Brück N
Pediatr Rheumatol Online J 2023 Sep 19;21(1):104. doi: 10.1186/s12969-023-00894-9. PMID: 37726751Free PMC Article
Magnetic resonance imaging findings of the lower limb muscles in anti-mitochondrial M2 antibody-positive myositis.
Nomiya H, Hamano T, Takaku N, Sasaki H, Usui K, Sanada S, Yamaguchi T, Kitazaki Y, Endo Y, Kamisawa T, Enomoto S, Shirafuji N, Matsunaga A, Ueno A, Ikawa M, Yamamura O, Hasegawa M, Kimura H, Nishino I, Nakamoto Y
Neuromuscul Disord 2023 Sep;33(9):74-80. Epub 2023 Jul 25 doi: 10.1016/j.nmd.2023.07.005. PMID: 37652755
Juvenile Dermatomyositis: Advances in Pathogenesis, Assessment, and Management.
Leung AKC, Lam JM, Alobaida S, Leong KF, Wong AHC
Curr Pediatr Rev 2021;17(4):273-287. doi: 10.2174/1573396317666210426105045. PMID: 33902423
Severe Abdominal Manifestations in Juvenile Dermatomyositis.
Besnard C, Gitiaux C, Girard M, Galmiche-Rolland L, Talbotec C, Quartier P, Bodemer C, Berteloot L, Bader-Meunier B
J Pediatr Gastroenterol Nutr 2020 Feb;70(2):247-251. doi: 10.1097/MPG.0000000000002575. PMID: 31978027

Recent systematic reviews

Myositis after SARS-CoV-2 vaccination occurs more frequently than assumed and is probably causally related.
Finsterer J, MohanaSundaram AS, Scorza F
Reumatismo 2023 Sep 18;75(3) doi: 10.4081/reumatismo.2023.1601. PMID: 37721345
Lung involvement in juvenile idiopathic inflammatory myopathy: A systematic review.
Abu-Rumeileh S, Marrani E, Maniscalco V, Maccora I, Pagnini I, Mastrolia MV, Rouster-Stevens K, Simonini G
Autoimmun Rev 2023 Oct;22(10):103416. Epub 2023 Aug 22 doi: 10.1016/j.autrev.2023.103416. PMID: 37611886
A Systematic Review and Metaanalysis of Predictors of Mortality in Idiopathic Inflammatory Myopathy-Associated Interstitial Lung Disease.
Hannah JR, Law HE, Gordon T, Rooney M, Buazon A, Adas M, Nagra D, Stovin C, Galloway J, Gordon PA
J Rheumatol 2023 Mar;50(3):373-383. Epub 2022 Sep 1 doi: 10.3899/jrheum.220383. PMID: 36379584
Use of Janus kinase inhibitors in dermatomyositis: a systematic literature review.
Paik JJ, Lubin G, Gromatzky A, Mudd PN Jr, Ponda MP, Christopher-Stine L
Clin Exp Rheumatol 2023 Mar;41(2):348-358. Epub 2022 Jun 28 doi: 10.55563/clinexprheumatol/hxin6o. PMID: 35766013Free PMC Article
Pregnancy in adult-onset dermatomyositis/polymyositis: A systematic review.
Tang K, Zhou J, Lan Y, Zhang H, Jin H
Am J Reprod Immunol 2022 Nov;88(5):e13603. Epub 2022 Aug 23 doi: 10.1111/aji.13603. PMID: 35867856

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